Journal article

Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis

Kazuhide S Okuda, Mikaela Keyser, David B Gurevich, Caterina Sturtzel, Elizabeth A Mason, Scott Patterson, Huijun Chen, Mark Scott, Nicholas D Condon, Paul Martin, Martin Distel, Benjamin M Hogan

ELIFE | ELIFE SCIENCES PUBLICATIONS LTD | Published : 2021

Abstract

The formation of new blood vessel networks occurs via angiogenesis during development, tissue repair, and disease. Angiogenesis is regulated by intracellular endothelial signalling pathways, induced downstream of vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs). A major challenge in understanding angiogenesis is interpreting how signalling events occur dynamically within endothelial cell populations during sprouting, proliferation, and migration. Extracellular signal-regulated kinase (Erk) is a central downstream effector of Vegf-signalling and reports the signalling that drives angiogenesis. We generated a vascular Erk biosensor transgenic line in zebrafish using a k..

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Grants

Awarded by National Health and Medical Research Council


Awarded by Austrian Research Promotion Agency


Funding Acknowledgements

National Health and Medical Research Council 1164734 Benjamin M Hogan ]National Health and Medical Research Council 1165117 Benjamin M HoganAustrian Research Promotion Agency 7640628 Martin DistelNational Health and Medical Research Council 1155221 Benjamin M Hogan