Journal article
Dynamic changes to tissue-resident immunity after MHC-matched and MHC-mismatched solid organ transplantation
A Prosser, WH Huang, L Liu, S Dart, M Watson, B de Boer, P Kendrew, A Lucas, I Larma-Cornwall, S Gaudieri, GP Jeffrey, L Delriviere, A Kallies, M Lucas
Cell Reports | CELL PRESS | Published : 2021
Abstract
The heterogeneous pool of tissue-resident lymphocytes in solid organs mediates infection responses and supports tissue integrity and repair. Their vital functions in normal physiology suggest an important role in solid organ transplantation; however, their detailed examination in this context has not been performed. Here, we report the fate of multiple lymphocyte subsets, including T, B, and innate lymphoid cells, after murine liver and heart transplantation. In major histocompatibility complex (MHC)-matched transplantation, donor lymphocytes are retained in liver grafts and peripheral lymphoid organs of heart and liver transplant recipients. In MHC-mismatched transplantation, increased infi..
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Awarded by National Institutes of Health
Funding Acknowledgements
We thank the Centre for Microscopy, Characterisation & Analysis, funded by The University of Western Australia (UWA) and Western Australian State and Australian Commonwealth governments; UWA Animal Care Services; and Dr. B. Lu, H. Li, and Dr. A. McDonnell for their assistance. The MR1 tetramer was developed by Dr. James McCluskey, Dr. Jamie Rossjohn, and Dr. David Fairlie and produced by the NIH Tetramer Core Facility as permitted to be distributed by the University of Melbourne. The Western Australian Department of Health, the Charlies Foundation for Research, and the Sir Charles Gairdner Hospital and Osborne Park Health Care Group (RAC 2018-19/030) funded this work. A.P. was supported by an Australian Government Research Training Program Scholarship, and A.K. was supported by a National Health and Medical Research Council Senior Research Fellowship (1139607).