Journal article

Three Small Molecule Entities (MPK18, MPK334 and YAK308) with Activity against Haemonchus contortus In Vitro

Aya C Taki, Abdul Jabbar, Thomas Kurz, Beate Lungerich, Guangxu Ma, Joseph J Byrne, Marc Pflieger, Yodita Asfaha, Fabian Fischer, Bill CH Chang, Brad E Sleebs, Robin B Gasser

MOLECULES | MDPI | Published : 2021

Abstract

Due to widespread multi-drug resistance in parasitic nematodes of livestock animals, there is an urgent need to discover new anthelmintics with distinct mechanisms of action. Extending previous work, here we screened a panel of 245 chemically-diverse small molecules for anti-parasitic activity against Haemonchus contortus-an economically important parasitic nematode of livestock. This panel was screened in vitro against exsheathed third-stage larvae (xL3) of H. contortus using an established phenotypic assay, and the potency of select compounds to inhibit larval motility and development assessed in dose-response assays. Of the 245 compounds screened, three-designated MPK18, MPK334 and YAK308..

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Grants

Awarded by German Research Foundation (DFG) Research Training Group GRK 2158


Funding Acknowledgements

This study was supported by the Australian Research Council (ARC), Yourgene Health Singapore Pte Ltd. (R.B.G.), and the German Research Foundation (DFG) Research Training Group GRK 2158 (270650915) (T.K.).