Journal article

Host IL11 Signaling Suppresses CD4( ) T cell-Mediated Antitumor Responses to Colon Cancer in Mice

Jennifer Huynh, David Baloyan, David Chisanga, Wei Shi, Megan O'Brien, Shoukat Afshar-Sterle, Mariah Alorro, Lokman Pang, David S Williams, Adam C Parslow, Pathum Thilakasiri, Moritz F Eissmann, Louis Boon, Frederick Masson, Ashwini L Chand, Matthias Ernst

CANCER IMMUNOLOGY RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2021

Abstract

IL11 is a member of the IL6 family of cytokines and signals through its cognate receptor subunits, IL11RA and glycoprotein 130 (GP130), to elicit biological responses via the JAK/STAT signaling pathway. IL11 contributes to cancer progression by promoting the survival and proliferation of cancer cells, but the potential immunomodulatory properties of IL11 signaling during tumor development have thus far remained unexplored. Here, we have characterized a role for IL11 in regulating CD4+ T cell-mediated antitumor responses. Absence of IL11 signaling impaired tumor growth in a sporadic mouse model of colon cancer and syngeneic allograft models of colon cancer. Adoptive bone marrow transfer exper..

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University of Melbourne Researchers

Grants

Awarded by NHMRC


Funding Acknowledgements

M. Ernst and A.L. Chand are recipients of Investigator and Fellowship support from the National Health and Medical Research Council (NHMRC) of Australia and the Victorian Cancer Agency, respectively. This work was supported in part by project grant 1125951 (to J. Huynh) from the NHMRC. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.