Disparate Effects of Diabetes and Hyperlipidemia on Experimental Kidney Disease.
Anna MD Watson, Eleanor AM Gould, Sarah C Moody, Priyadharshini Sivakumaran, Karly C Sourris, Bryna SM Chow, Audrey Koïtka-Weber, Terri J Allen, Karin AM Jandeleit-Dahm, Mark E Cooper, Anna C Calkin
Front Physiol | Frontiers Media SA | Published : 2020
It is well established that diabetes is the major cause of chronic kidney disease worldwide. Both hyperglycemia, and more recently, advanced glycation endproducts, have been shown to play critical roles in the development of kidney disease. Moreover, the renin-angiotensin system along with growth factors and cytokines have also been shown to contribute to the onset and progression of diabetic kidney disease; however, the role of lipids in this context is poorly characterized. The current study aimed to compare the effect of 20 weeks of streptozotocin-induced diabetes or western diet feeding on kidney disease in two different mouse strains, C57BL/6 mice and hyperlipidemic apolipoprotein (apo)..View full abstract