Journal article

IDOL regulates systemic energy balance through control of neuronal VLDLR expression.

Stephen D Lee, Christina Priest, Mikael Bjursell, Jie Gao, Douglas V Arneson, In Sook Ahn, Graciel Diamante, J Edward van Veen, Megan G Massa, Anna C Calkin, Jason Kim, Harriet Andersén, Prashant Rajbhandari, Michelle Porritt, Alba Carreras, Andrea Ahnmark, Frank Seeliger, Ingela Maxvall, Pernilla Eliasson, Magnus Althage Show all

Nat Metab | Springer Science and Business Media LLC | Published : 2019

Abstract

Liver X receptors limit cellular lipid uptake by stimulating the transcription of Inducible Degrader of the LDL Receptor (IDOL), an E3 ubiquitin ligase that targets lipoprotein receptors for degradation. The function of IDOL in systemic metabolism is incompletely understood. Here we show that loss of IDOL in mice protects against the development of diet-induced obesity and metabolic dysfunction by altering food intake and thermogenesis. Unexpectedly, analysis of tissue-specific knockout mice revealed that IDOL affects energy balance, not through its actions in peripheral metabolic tissues (liver, adipose, endothelium, intestine, skeletal muscle), but by controlling lipoprotein receptor abund..

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