Anesthetic technique and cancer surgery outcomes
Julia Dubowitz, Jonathan Hiller, Bernhard Riedel
CURRENT OPINION IN ANESTHESIOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021
PURPOSE OF REVIEW: Surgery remains integral to treating solid cancers. However, the surgical stress response, characterized by physiologic perturbation of the adrenergic, inflammatory, and immune systems, may promote procancerous pathways. Anesthetic technique per se may attenuate/enhance these pathways and thereby could be implicated in long-term cancer outcomes. RECENT FINDINGS: To date, clinical studies have predominantly been retrospective and underpowered and, thus limit meaningful conclusions. More recently, prospective studies of regional anesthesia for breast and colorectal cancer surgery have failed to demonstrate long-term cancer outcome benefit. However, based on the consistent ob..View full abstract
Awarded by National Health and Medical Research Council of Australia
Professor Riedel has received honoraria from Edwards Life Sciences and MSD for unrelated work. The remaining authors have no conflicts of interest. The authors are investigators on a current grant (NHMRC: GNT1160191) from the National Health and Medical Research Council of Australia that supports the VAPORC study.