Journal article

White matter changes in psychosis risk relate to development and are not impacted by the transition to psychosis

Maria A Di Biase, Suheyla Cetin-Karayumak, Amanda E Lyall, Andrew Zalesky, Kang Ik Kevin Cho, Fan Zhang, Marek Kubicki, Yogesh Rathi, Monica G Lyons, Sylvain Bouix, Tashrif Billah, Alan Anticevic, Charlie Schleifer, Brendan D Adkinson, Jie Lisa Ji, Zailyn Tamayo, Jean Addington, Carrie E Bearden, Barbara A Cornblatt, Matcheri S Keshavan Show all

MOLECULAR PSYCHIATRY | SPRINGERNATURE | Published : 2021

Abstract

Subtle alterations in white matter microstructure are observed in youth at clinical high risk (CHR) for psychosis. However, the timing of these changes and their relationships to the emergence of psychosis remain unclear. Here, we track the evolution of white matter abnormalities in a large, longitudinal cohort of CHR individuals comprising the North American Prodrome Longitudinal Study (NAPLS-3). Multi-shell diffusion magnetic resonance imaging data were collected across multiple timepoints (1-5 over 1 year) in 286 subjects (aged 12-32 years): 25 CHR individuals who transitioned to psychosis (CHR-P; 61 scans), 205 CHR subjects with unknown transition outcome after the 1-year follow-up perio..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC) Investigator Grant


Awarded by National Institute of Mental Health


Funding Acknowledgements

MADB was supported by an Australian National Health and Medical Research Council (NHMRC) Investigator Grant (1175754). This study was supported by a National Alliance for Research on Schizophrenia & Depression (NARSAD) Brain and Behavior Research Foundation Young Investigator Award (to AEL) and by the National Institute of Mental Health (grant K01 MH115247-01A1 to AEL; grants R01MH108574, R01MH102377, R01MH074794, P41EB015902 to OP; grant U01MH081984 to JA; grant U01MH081928 to WSS; grant U01MH081944 to KSC; grant U01MH081902 to TDC and CEB; grant U01MH082004 to DOP; grant U01MH082022 to SWW; grant U01MH076989 to DHM; grant U01MH081857 to BAC; and, grant U01MH109977 to MES).