Journal article

Abstract 13147: Non-invasive Identification of Carditis in Acute Rheumatic Fever and Rheumatic Heart Disease

Sarah J Gutman, Benedict T Costello, Melissa G van Leeuwen, Jessica O'Brien, Seeba E Varghese, Leah Wright, Stephen Brady, Christopher Wong, Graeme Maguire, Thomas H Marwick, Andrew J Taylor

Circulation | Ovid Technologies (Wolters Kluwer Health) | Published : 2020

Abstract

Background: The pathogenesis of acute rheumatic fever (ARF) and its evolution into rheumatic heart disease (RHD) is poorly understood. We aimed to identify carditis in patients with ARF and RHD using cardiac magnetic resonance (CMR) tissue characterisation with T1 mapping. We hypothesised that prolonged native T1 time on CMR, would be present in ARF and RHD patients. Methods: We prospectively recruited 62 patients. We recruited 16 patients fulfilling the Jones Criteria for the diagnosis of ARF, 15 controls with an inflammatory condition and 10 healthy controls. We also recruited 11 patients with echocardiographic evidence of RHD and 1..

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University of Melbourne Researchers