Journal article

Mu-opioid receptors in septum mediate the development of behavioural sensitization to a single morphine exposure in male rats

Yu-Ling Li, Shoupeng Wei, Qing Liu, Qi Gong, Qing-Jie Zhang, Tian-Ge Zheng, Zheng Yong, Feng Chen, Andrew J Lawrence, Jian-Hui Liang

Addiction Biology | WILEY | Published : 2021

Abstract

Behavioural sensitization (BS) is characterized by enhanced psychomotor responses to a dose of substance of abuse after prior repeated exposure. We previously reported that BS can be induced by a single injection of morphine in rats, whereas septal nuclei are specifically involved in the development phase of BS. Here, we demonstrated that intra-LS or intra-MS microinjections also incubated BS to a systemic morphine injection in a cross-sensitization fashion, whereas inactivation of either subdivision of septal nuclei (LS: lateral septum; MS: medial septum) can negate this ability of morphine. Then, non-selective (naloxone) and selective (μ-, δ- and κ-)opioid receptor antagonists were directl..

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Grants

Awarded by National Key Technology R&D Program in the 12th Five Year Plan of China


Awarded by National Nature Science Foundation of China


Funding Acknowledgements

National Key Technology R&D Program in the 12th Five Year Plan of China, Grant/Award Number: 2011BAK04B08; National Nature Science Foundation of China, Grant/Award Number: 81773705; National Health and Medical Research Council (Australia)