Multimodality Intravascular Imaging of High-Risk Coronary Plaque.
Jiawen Li, Nicholas J Montarello, Ayla Hoogendoorn, Johan W Verjans, Christina A Bursill, Karlheinz Peter, Stephen J Nicholls, Robert A McLaughlin, Peter J Psaltis
JACC Cardiovasc Imaging | Published : 2022
The majority of coronary atherothrombotic events presenting as myocardial infarction (MI) occur as a result of plaque rupture or erosion. Understanding the evolution from a stable plaque into a life-threatening, high-risk plaque is required for advancing clinical approaches to predict atherothrombotic events, and better treat coronary atherosclerosis. Unfortunately, none of the coronary imaging approaches used in clinical practice can reliably predict which plaques will cause an MI. Currently used imaging techniques mostly identify morphological features of plaques, but are not capable of detecting essential molecular characteristics known to be important drivers of future risk. To address t..View full abstract