Journal article

Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice

Sudip Paul, Aliki A Rasmiena, Kevin Huynh, Adam Alexander T Smith, Natalie A Mellett, Karin Jandeleit-Dahm, Graeme I Lancaster, Peter J Meikle

Metabolites | MDPI | Published : 2021

Abstract

Plasmalogens or alkenylphospholipids are a sub-class of glycerophospholipids with numerous biological functions and are thought to have protective effects against metabolic disease. Dietary supplementation with alkylglycerols (AKGs) has been shown to increase endogenous plasmalogen levels, however effective modulation of different molecular plasmalogen species has not yet been demonstrated. In this study, the effects of an orally-administered AKG mix (a mixture of chimyl, batyl and selachyl alcohol at a 1:1:1 ratio) on plasma and tissue lipids, including plasmalogens, was evaluated. Mice on a Western-type diet were treated with either an AKG mix or vehicle (lecithin) for 1, 2, 4, 8 and 12 we..

View full abstract

Grants

Awarded by National Health and Medical Research Council of Australia Senior Research Fellowship


Funding Acknowledgements

S.P. was supported by a Monash Graduate Scholarship and a Faculty Graduate Research International Scholarship from Monash University; P.J.M. was supported by a National Health and Medical Research Council of Australia Senior Research Fellowship (#1042095).