Journal article

Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malaria

Zalak Shah, Myo T Naung, Kara A Moser, Matthew Adams, Andrea G Buchwald, Ankit Dwivedi, Amed Ouattara, Karl B Seydel, Don P Mathanga, Alyssa E Barry, David Serre, Miriam K Laufer, Joana C Silva, Shannon Takala-Harrison

PLOS GENETICS | PUBLIC LIBRARY SCIENCE | Published : 2021

Abstract

Individuals acquire immunity to clinical malaria after repeated Plasmodium falciparum infections. Immunity to disease is thought to reflect the acquisition of a repertoire of responses to multiple alleles in diverse parasite antigens. In previous studies, we identified polymorphic sites within individual antigens that are associated with parasite immune evasion by examining antigen allele dynamics in individuals followed longitudinally. Here we expand this approach by analyzing genome-wide polymorphisms using whole genome sequence data from 140 parasite isolates representing malaria cases from a longitudinal study in Malawi and identify 25 genes that encode possible targets of naturally acqu..

View full abstract

University of Melbourne Researchers

Grants

Awarded by National Institutes of Health


Awarded by Malawi International Center of Excellence for Malaria Research


Awarded by National Health and Medical Research Council: NHMRC


Funding Acknowledgements

This work was supported by funding from the following awards granted by the National Institutes of Health: R01AI101713 (ST-H), R01AI125579 (ST-H), R01AI141900 (JCS), U19AI110820 (PI: Fraser, Project Lead: JCS), K24AI114996 (MKL), and the Malawi International Center of Excellence for Malaria Research U19AI089683 (DPM), as well as an award from the National Health and Medical Research Council: NHMRC APP1161066 (AEB, ST-H). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.