Global economic costs due to vivax malaria and the potential impact of its radical cure: A modelling study

Angela Devine; Katherine E Battle; Niamh Meagher; Rosalind E Howes; Saber Dini; Peter W Gething; Julie A Simpson; Ric N Price; Yoel Lubell

Journal article

Global economic costs due to vivax malaria and the potential impact of its radical cure: A modelling study

Angela Devine, Katherine E Battle, Niamh Meagher, Rosalind E Howes, Saber Dini, Peter W Gething, Julie A Simpson, Ric N Price, Yoel Lubell

PLOS MEDICINE | PUBLIC LIBRARY SCIENCE | Published : 2021

DOI: 10.1371/journal.pmed.1003614

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Abstract

BACKGROUND: In 2017, an estimated 14 million cases of Plasmodium vivax malaria were reported from Asia, Central and South America, and the Horn of Africa. The clinical burden of vivax malaria is largely driven by its ability to form dormant liver stages (hypnozoites) that can reactivate to cause recurrent episodes of malaria. Elimination of both the blood and liver stages of the parasites ("radical cure") is required to achieve a sustained clinical response and prevent ongoing transmission of the parasite. Novel treatment options and point-of-care diagnostics are now available to ensure that radical cure can be administered safely and effectively. We quantified the global economic cost of vi..

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University of Melbourne Researchers

Angela Devine Author Melbourne School of Population and Global Health

Niamh Meagher Author Infectious Diseases

Saber Dini Author Melbourne School of Population and Global Health

Julie Simpson Author Melbourne School of Population and Global Health

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Grants

Awarded by Bill & Melinda Gates Foundation

Awarded by National Health and Medical Research Council of Australia through the Australian Centre for Research Excellence on Malaria Elimination (ACREME)

Funding Acknowledgements

This work was funded by the Bill & Melinda Gates Foundation (https://www.gatesfoundation.org) to RNP (INV-007122). Funding was also received from the National Health and Medical Research Council of Australia (https://www.nhmrc.gov.au) through the Australian Centre for Research Excellence on Malaria Elimination (ACREME) to JAS, RNP (1134989). RNP is a Wellcome Trust (https://wellcome.org/) Senior Fellow in Clinical Science (200909) and JAS is a National Health and Medical Research Council of Australia (https://www.nhmrc.gov.au) Senior Research Fellow (1104975). PWG is supported by the Bill and Melinda Gates Foundation (https://www.gatesfoundation.org, INV-009390) and the Telethon Trust (https://www.telethon7.com), Western Australia. The funders did not participate in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.