Positron emission tomography and magnetic resonance imaging in experimental human malaria to identify organ-specific changes in morphology and glucose metabolism: A prospective cohort study
John Woodford, Ashley Gillman, Peter Jenvey, Jennie Roberts, Stephen Woolley, Bridget E Barber, Melissa Fernandez, Stephen Rose, Paul Thomas, Nicholas M Anstey, James S McCarthy
PLOS MEDICINE | PUBLIC LIBRARY SCIENCE | Published : 2021
BACKGROUND: Plasmodium vivax has been proposed to infect and replicate in the human spleen and bone marrow. Compared to Plasmodium falciparum, which is known to undergo microvascular tissue sequestration, little is known about the behavior of P. vivax outside of the circulating compartment. This may be due in part to difficulties in studying parasite location and activity in life. METHODS AND FINDINGS: To identify organ-specific changes during the early stages of P. vivax infection, we performed 18-F fluorodeoxyglucose (FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) at baseline and just prior to onset of clinical illness in P. vivax experimentally induced blood-stage ..View full abstract
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Awarded by Australian National Health and Medical Research Council
Awarded by Bill and Melinda Gates Foundation
This project was supported by a HIRF Seed Funding Grant, Metro North Hospital and Health Service (J.W) and by the Australian National Health and Medical Research Council (J.S.M #1135955, #1037304, #1132975, and N.M.A #1135820, 1098334). The clinical trials contributing participants were funded by the Australian National Health and Medical Research Council (J.S.M #1132975), the Bill and Melinda Gates Foundation (J.S.M OPP1111147) and the Global Health Innovative Technology Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.