Barrett's esophagus with low-grade dysplasia: high rate of upstaging at Barrett's esophagus referral units suggests progression rates may be overestimated.
Edward H Tsoi, Puneet Mahindra, Georgina Cameron, Richard Williams, Richard Norris, Paul V Desmond, Spiro Raftopoulos, Darren Pavey, Arti Rattan, Luke F Hourigan, Richard Lee, Michael J Bourke, Naaz Sidhu, Rajvinder Singh, Andrew Chan, Sudarshan Krishnamurthi, Andrew Cf Taylor
Gastrointest Endosc | Published : 2021
BACKGROUND AND AIMS: The reported progression rate from low-grade dysplasia (LGD) in Barrett's esophagus (BE) to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC) ranges from 0.4% to 13.4% per year. We hypothesize that some of the reported progression rates may be overestimated due to prevalent HGD or EAC, which was not identified during endoscopic assessments performed in the community. The aim is to determine the proportion of prevalent HGD or EAC detected by Barrett's esophagus referral units (BERU) in patients referred from the community with a recent diagnosis of LGD. METHODS: All patients referred from the community to 6 BERU with a diagnosis of BE with LGD were identified...View full abstract