Journal article
Overcoming bacteriophage insensitivity in Staphylococcus aureus using clindamycin and azithromycinat subinhibitory concentrations
S Liu, Y Zhao, A Hayes, K Hon, G Zhang, C Bennett, H Hu, J Finnie, S Morales, L Shearwin, AJ Psaltis, K Shearwin, PJ Wormald, S Vreugde
Allergy European Journal of Allergy and Clinical Immunology | Published : 2021
DOI: 10.1111/all.14883
Abstract
Background: Staphylococcus aureus is a pathogen of major concern in both acute infections and chronic conditions such as chronic rhinosinusitis (CRS). Bacteriophage (phage) therapy has recently regained interest for its potential to treat infections caused by antibiotic resistant strains including Methicillin Resistant Staphylococcus aureus (MRSA). However, bacteria can adapt and become resistant to phages. The aim of this study is to determine the potential for antibiotics to overcome phage resistance. Methods: The susceptibility of S. aureus clinical isolates (CIs) to phages J-Sa36, Sa83 and Sa87 alone or in combination with protein synthesis inhibitor (PSI) antibiotics clindamycin, azithr..
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