Journal article

Geospatial clustering and modelling provide policy guidance to distribute funding for active TB case finding in Ethiopia

Debebe Shaweno, James M Trauer, Tan N Doan, Justin T Denholm, Emma S McBryde

EPIDEMICS | ELSEVIER | Published : 2021

Abstract

Tuberculosis (TB) exhibits considerable spatial heterogeneity, occurring in clusters that may act as hubs of community transmission. We evaluated the impact of an intervention targeting spatial TB hotspots in a rural region of Ethiopia. To evaluate the impact of targeted active case finding (ACF), we used a spatially structured mathematical model that has previously been described. From model equilibrium, we simulated the impact of a hotspot-targeted strategy (HTS) on TB incidence ten years from intervention commencement and the associated cost-effectiveness. HTS was also compared with an untargeted strategy (UTS). We used logistic cost-coverage analysis to estimate cost-effectiveness of int..

View full abstract

Grants

Awarded by NHMRC


Funding Acknowledgements

No specific funding was received for this study. Debebe Shaweno is the recipient of the Melbourne International Research Scholarship and Melbourne International Fee Remission Scholarship. James Trauer is a recipient of an Early Career Fellowship from the NHMRC (APP1142638).