The Ribosomal Gene Loci-The Power behind the Throne
Konstantin I Panov, Katherine Hannan, Ross D Hannan, Nadine Hein
GENES | MDPI | Published : 2021
Nucleoli form around actively transcribed ribosomal RNA (rRNA) genes (rDNA), and the morphology and location of nucleolus-associated genomic domains (NADs) are linked to the RNA Polymerase I (Pol I) transcription status. The number of rDNA repeats (and the proportion of actively transcribed rRNA genes) is variable between cell types, individuals and disease state. Substantial changes in nucleolar morphology and size accompanied by concomitant changes in the Pol I transcription rate have long been documented during normal cell cycle progression, development and malignant transformation. This demonstrates how dynamic the nucleolar structure can be. Here, we will discuss how the structure of th..View full abstract
This was funded by R.D.H NHMRC fellowship and grant; N.H NHMRC grant.