Journal article
A meta-analysis of obesity and risk of colorectal cancer in patients with lynch syndrome: The impact of sex and genetics
M Lazzeroni, F Bellerba, M Calvello, F Macrae, AK Win, M Jenkins, D Serrano, M Marabelli, S Cagnacci, G Tolva, D Macis, S Raimondi, L Mazzarella, S Chiocca, S Caini, L Bertario, B Bonanni, S Gandini
Nutrients | MDPI | Published : 2021
DOI: 10.3390/nu13051736
Open access
Abstract
There appears to be a sex-specific association between obesity and colorectal neoplasia in patients with Lynch Syndrome (LS). We meta-analyzed studies reporting on obesity and colorectal cancer (CRC) risk in LS patients to test whether obese subjects were at increased risk of cancer compared to those of normal weight. We explored also a possible sex-specific relationship between adiposity and CRC risk among patients with LS. The summary relative risk (SRR) and 95% confidence intervals (CI) were calculated through random effect models. We investigated the causes of between-study heterogeneity and assessed the presence of publication bias. We were able to retrieve suitable data from four indep..
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Awarded by Ministero della Salute
Funding Acknowledgements
We thank Margherita Omesso for writing assistance. This work was partially supported by the Italian Ministry of Health with Ricerca Corrente and 5 x 1000 funds. T.G. was a recipient of a fellowship from the IEO-CCM Foundation. Federica Bellerba is a PhD student at the European School of Molecular Medicine (SEMM), Milan, Italy.