A Meta-Analysis of Obesity and Risk of Colorectal Cancer in Patients with Lynch Syndrome: The Impact of Sex and Genetics.
Matteo Lazzeroni, Federica Bellerba, Mariarosaria Calvello, Finlay Macrae, Aung Ko Win, Mark Jenkins, Davide Serrano, Monica Marabelli, Sara Cagnacci, Gianluca Tolva, Debora Macis, Sara Raimondi, Luca Mazzarella, Susanna Chiocca, Saverio Caini, Lucio Bertario, Bernardo Bonanni, Sara Gandini
Nutrients | Published : 2021
There appears to be a sex-specific association between obesity and colorectal neoplasia in patients with Lynch Syndrome (LS). We meta-analyzed studies reporting on obesity and colorectal cancer (CRC) risk in LS patients to test whether obese subjects were at increased risk of cancer compared to those of normal weight. We explored also a possible sex-specific relationship between adiposity and CRC risk among patients with LS. The summary relative risk (SRR) and 95% confidence intervals (CI) were calculated through random effect models. We investigated the causes of between-study heterogeneity and assessed the presence of publication bias. We were able to retrieve suitable data from four indep..View full abstract