Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer's Disease

C Fowler; SR Rainey-Smith; S Bird; J Bomke; P Bourgeat; BM Brown; SC Burnham; AI Bush; C Chadunow; S Collins; J Doecke; V Doré; KA Ellis; L Evered; A Fazlollahi; J Fripp; SL Gardener; S Gibson; R Grenfell; E Harrison; R Head; L Jin; A Kamer; F Lamb; NT Lautenschlager; SM Laws; QX Li; L Lim; YY Lim; A Louey; SL MacAulay; L MacKintosh; RN Martins; P Maruff; CL Masters; S McBride; L Milicic; M Peretti; K Pertile; T Porter; M Radler; A Rembach; J Robertson; M Rodrigues; CC Rowe; R Rumble; O Salvado; G Savage; B Silbert; M Soh; HR Sohrabi; K Taddei; T Taddei; C Thai; B Trounson; R Tyrrell; M Vacher; S Varghese; VL Villemagne; M Weinborn; M Woodward; Y Xia; D Ames

Journal article

Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer's Disease

C Fowler, SR Rainey-Smith, S Bird, J Bomke, P Bourgeat, BM Brown, SC Burnham, AI Bush, C Chadunow, S Collins, J Doecke, V Doré, KA Ellis, L Evered, A Fazlollahi, J Fripp, SL Gardener, S Gibson, R Grenfell, E Harrison Show all

Journal of Alzheimer S Disease Reports | Published : 2021

DOI: 10.3233/ADR-210005

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Abstract

Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in 2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild cognitive impairment (MCI), and 211 with Alzheimer's disease dementia (AD)) as an 'Inception cohort' who underwent detailed ssessments every 18 months. Over the past decade, an additional 1247 subjects have been added as an 'Enrichment cohort' (as of 10 April 2019). Objective: Here we provide an overview of these Inception and Enrichment cohorts of more than 8,500 person-years of investigation. Methods: Participants underwent reassessment every 18 months including comprehensive cognitive testing, neuroimaging (magn..

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University of Melbourne Researchers

Ashley Bush Author

Steven Collins Author

Kathryn Ellis Author

Lis Evered Author

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

The AIBL study (www.AIBL.csiro.au) is a consortium between Austin Health, CSIRO, Edith Cowan University, the Florey Institute (The University of Melbourne), and the National Ageing Research Institute. The study has received partial financial support from the Alzheimer's Association (US), the Alzheimer's Drug Discovery Foundation, an Anonymous foundation, the Science and Industry Endowment Fund, the Dementia Collaborative Research Centres, the Victorian Government's Operational Infrastructure Support program, the Australian Alzheimer's Research Foundation, the National Health and Medical Research Council (NHMRC), and The Yulgilbar Foundation. Numerous commercial interactions have supported data collection and analyses. In-kind support has also been provided by Sir Charles Gairdner Hospital, Cogstate Ltd, Hollywood Private Hospital, The University of Melbourne, and St Vincent's Hospital. SRRS is supported by an NHMRC Investigator Grant (GNT1197315). YYL is supported by an NHMRC Career Development Fellowship (GNT1162645).