Journal article

Procalcitonin and Interleukin-10 May Assist in Early Prediction of Bacteraemia in Children With Cancer and Febrile Neutropenia

Marcel Doerflinger, Gabrielle M Haeusler, Connie SN Li-Wai-Suen, Julia E Clark, Monica Slavin, Franz E Babl, Zoe Allaway, Francoise Mechinaud, Gordon K Smyth, Richard De Abreu Lourenco, Bob Phillips, Marc Pellegrini, Karin A Thursky

FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2021

Abstract

Objectives: Febrile neutropenia (FN) causes treatment disruption and unplanned hospitalization in children with cancer. Serum biomarkers are infrequently used to stratify these patients into high or low risk for serious infection. This study investigated plasma abundance of cytokines in children with FN and their ability to predict bacteraemia. Methods: Thirty-three plasma cytokines, C-reactive protein (CRP) and procalcitonin (PCT) were measured using ELISA assays in samples taken at FN presentation (n = 79) and within 8-24 h (Day 2; n = 31). Optimal thresholds for prediction of bacteraemia were identified and the predictive ability of biomarkers in addition to routinely available clinical v..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

This study was funded by a National Health and Medical Research Council (NHMRC) Project Grant (APP1104527). We gratefully acknowledge the support and endorsement of the Australian and New Zealand Children's Haematology/Oncology Group (ANZCHOG) and the Paediatric Research in Emergency Departments International Collaborative (PREDICT).