Thesis / Dissertation

Identifying and addressing limitations in deep brain stimulation for Parkinson's disease using novel neuronal biomarkers

SanSan Xu, Wesley Thevathasan (ed.)

Published : 2020


Deep brain stimulation (DBS) is an effective treatment in Parkinson’s disease (PD). DBS is postulated to modulate and restore ‘functionality’ to the pathological brain networks implicated in PD. DBS therapy improves motor symptoms and quality of life and allows for substantial medication reduction. However, there is little information on the long-term outcomes after DBS implantation including programming rates, battery changes, hardware complication surgeries or the duration of the therapy. This knowledge is crucial to inform on clinical decision making, distribution of healthcare resources and guide research direction for device development. The first part of this thesis presents a cross-..

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