Thesis / Dissertation

Nanoengineering Antibody Assemblies for Biomedical Applications

Yingjie Hu, Francesco Caruso (ed.)

Published : 2021

Abstract

The clinical success of monoclonal antibody therapy has inspired research in understanding the fundamental molecular basis of antibody-antigen interactions and the engineering of antibodies with enhanced or novel properties. With the emergence of nanomedicine, antibodies have been widely applied as targeting ligands decorated on the surface of therapeutic nanostructured modalities – including liposomes, protein nanoparticles, and polymeric assemblies – for drug delivery and imaging applications. However, little is known about how antibodies assembled in a cluster or particulate form interact with antigens in a biological system, largely due to the challenge in preparing ‘pure’ antibody assem..

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University of Melbourne Researchers