Thesis / Dissertation

The role of the MiT/TFE family of transcription factors in cytotoxic secretory granule formation in cytotoxic Tlymphocytes and the Niemann-Pick type C1 disease as a model

Daniela Castiblanco Gaitan, Ilia Voskoboinik (ed.)

Published : 2021

Abstract

Cytotoxic secretory granules (CGs) are unique and specialised lysosomal organelles found specifically in cytotoxic lymphocytes: Natural Killer (NK) cells and CD8+ T cells or Cytotoxic T-Lymphocytes (CTLs). CGs precisely store and deliver perforin and granzymes; molecules that synergistically induce the controlled death of infected and neoplastic cells. The precise molecular mechanisms that govern CG formation remain poorly understood and this work aimed to explore the potential role of the MiT/TFE family of proteins in transcriptionally regulating this process. Three members of the MiT/TFE family (MITF, TFEB and TFE3) are largely recognised as the master regulators of lysosome biogenesis and..

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