Journal article
Serological differentiation between COVID-19 and SARS infections
WN Chia, CW Tan, R Foo, AEZ Kang, Y Peng, V Sivalingam, C Tiu, XM Ong, F Zhu, BE Young, MIC Chen, YJ Tan, DC Lye, DE Anderson, LF Wang
Emerging Microbes and Infections | TAYLOR & FRANCIS LTD | Published : 2020
Open access
Abstract
In response to the coronavirus disease 2019 (COVID-19) outbreak, caused by SARS-CoV-2, multiple diagnostic tests are required for acute disease diagnosis, contact tracing, monitoring asymptomatic infection rates and assessing herd immunity. While PCR remains the frontline test of choice in the acute diagnostic setting, serological tests are urgently needed. Unlike PCR tests which are highly specific, cross-reactivity is a major challenge for COVID-19 antibody tests considering there are six other coronaviruses known to infect humans. SARS-CoV is genetically related to SARS-CoV-2 sharing approximately 80% sequence identity and both belong to the species SARS related coronavirus in the genus B..
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Awarded by National Medical Research Council
Funding Acknowledgements
This work is supported in part by the Singapore Singapore Medical Research Council (NMRC) grants STPRG-FY19-001 and COVID19RF-003, and Singapore National Research Foundation (NRF) grant NRF2016NRF-NSFC002-013.