Journal article
Long-term humoral immune response in persons with asymptomatic or mild SARS-CoV-2 infection, Vietnam
HK Mai, NB Trieu, TH Long, HT Thanh, ND Luong, LX Huy, LA Nguyet, DN Huy Man, DE Anderson, TT Thanh, N van Vinh Chau, G Thwaites, LF Wang, Le Van Tan, DT Hung
Emerging Infectious Diseases | CENTERS DISEASE CONTROL & PREVENTION | Published : 2021
Open access
Abstract
Antibody response against nucleocapsid and spike proteins of SARS-CoV-2 in 11 persons with mild or asymptomatic infection rapidly increased after infection. At weeks 18-30 after diagnosis, all remained seropositive but spike protein-targeting antibody titers declined. These data may be useful for vaccine development.
Grants
Awarded by Centers for Disease Control and Prevention
Funding Acknowledgements
This study was funded by the World Health Organization and the US Centers for Disease Control and Prevention through the Field Epidemiology of Training Programmes. L.V.T. and G.T. are supported by the Wellcome Trust of Great Britain (204904/Z/16/Z and 106680/B/14/Z, respectively). The serology work at Duke-NUS is supported by grants from the National Medical Research Council, Singapore (STPRG-FY19-001 and COVID19RF-003).