Journal article

Long-Term Humoral Immune Response in Persons with Asymptomatic or Mild SARS-CoV-2 Infection, Vietnam

Kim Mai Huynh, Bao Trieu Nguyen, Hoang Long Trinh, Tien Thanh Hoang, Dinh Luong Nguyen, Xuan Huy Le, Anh Nguyet Lam, Nguyen Huy Man Dinh, Danielle E Anderson, Tan Thanh Tran, Van Vinh Chau Nguyen, Guy Thwaites, Wang Lin-Fa, Van Tan Le, Thai Hung Do

Emerging Infectious Diseases | CENTERS DISEASE CONTROL & PREVENTION | Published : 2021

Abstract

Antibody response against nucleocapsid and spike proteins of SARS-CoV-2 in 11 persons with mild or asymptomatic infection rapidly increased after infection. At weeks 18-30 after diagnosis, all remained seropositive but spike protein-targeting antibody titers declined. These data may be useful for vaccine development.

Grants

Awarded by Wellcome Trust of Great Britain


Awarded by National Medical Research Council, Singapore


Funding Acknowledgements

This study was funded by the World Health Organization and the US Centers for Disease Control and Prevention through the Field Epidemiology of Training Programmes. L.V.T. and G.T. are supported by the Wellcome Trust of Great Britain (204904/Z/16/Z and 106680/B/14/Z, respectively). The serology work at Duke-NUS is supported by grants from the National Medical Research Council, Singapore (STPRG-FY19-001 and COVID19RF-003).