Region between the Canine Distemper Virus M and F Genes Modulates Virulence by Controlling Fusion Protein Expression
Danielle E Anderson, Veronika von Messling
Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2008
Morbilliviruses, including measles and canine distemper virus (CDV), are nonsegmented, negative-stranded RNA viruses that cause severe diseases in humans and animals. The transcriptional units in their genomes are separated by untranslated regions (UTRs), which contain essential transcription and translation signals. Due to its increased length, the region between the matrix (M) protein and fusion (F) protein open reading frames is of particular interest. In measles virus, the entire F 5' region is untranslated, while several start codons are found in most other morbilliviruses, resulting in a long F protein signal peptide (Fsp). To characterize the role of this region in morbillivirus patho..View full abstract
Awarded by CIHR
Awarded by CFI
This work was supported by grants from the CIHR (MOP-66989), CFI (9488) to V. V. M. and an Armand-Frappier Foundation fellowship to D. E. A.