Journal article

Canine Distemper Virus Matrix Protein Influences Particle Infectivity, Particle Composition, and Envelope Distribution in Polarized Epithelial Cells and Modulates Virulence

Erik Dietzel, Danielle E Anderson, Alexandre Castan, Veronika von Messling, Andrea Maisner

Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2011

Abstract

In paramyxoviruses, the matrix (M) protein mediates the interaction between the envelope and internal proteins during particle assembly and egress. In measles virus (MeV), M mutations, such as those found in subacute sclerosing panencephalitis (SSPE) strains, and differences in vaccine and wild-type M proteins can affect the strength of interaction with the envelope glycoproteins, assembly efficiency, and spread. However, the contribution of the M protein to the replication and pathogenesis of the closely related canine distemper virus (CDV) has not been characterized. To this end this, we generated a recombinant wild-type CDV carrying a vaccine strain M protein. The recombinant virus retain..

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Grants

Awarded by German Research Foundation (DFG)


Awarded by Canadian Institutes of Health Research


Awarded by Canadian Foundation for Innovation


Funding Acknowledgements

This work was supported by grants from the German Research Foundation (DFG) to A. M. (MA 1886/6-1) and by grants to V. V. M. from the Canadian Institutes of Health Research (MOP-66989) and the Canadian Foundation for Innovation (9488).