Canine Distemper Virus Matrix Protein Influences Particle Infectivity, Particle Composition, and Envelope Distribution in Polarized Epithelial Cells and Modulates Virulence
Erik Dietzel, Danielle E Anderson, Alexandre Castan, Veronika von Messling, Andrea Maisner
Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2011
In paramyxoviruses, the matrix (M) protein mediates the interaction between the envelope and internal proteins during particle assembly and egress. In measles virus (MeV), M mutations, such as those found in subacute sclerosing panencephalitis (SSPE) strains, and differences in vaccine and wild-type M proteins can affect the strength of interaction with the envelope glycoproteins, assembly efficiency, and spread. However, the contribution of the M protein to the replication and pathogenesis of the closely related canine distemper virus (CDV) has not been characterized. To this end this, we generated a recombinant wild-type CDV carrying a vaccine strain M protein. The recombinant virus retain..View full abstract
Awarded by German Research Foundation (DFG)
Awarded by Canadian Institutes of Health Research
Awarded by Canadian Foundation for Innovation
This work was supported by grants from the German Research Foundation (DFG) to A. M. (MA 1886/6-1) and by grants to V. V. M. from the Canadian Institutes of Health Research (MOP-66989) and the Canadian Foundation for Innovation (9488).