Journal article
Viral dynamics and immune correlates of coronavirus disease 2019 (COVID-19) severity
BE Young, SWX Ong, LFP Ng, DE Anderson, WN Chia, PY Chia, LW Ang, TM Mak, S Kalimuddin, LYA Chai, S Pada, SY Tan, L Sun, P Parthasarathy, SW Fong, YH Chan, CW Tan, B Lee, O Rötzschke, Y Ding Show all
Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2021
DOI: 10.1093/cid/ciaa1280
Abstract
Background. Key knowledge gaps remain in the understanding of viral dynamics and immune response of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Methods. We evaluated these characteristics and established their association with clinical severity in a prospective observational cohort study of 100 patients with PCR-confirmed SARS-CoV-2 infection (mean age, 46 years; 56% male; 38% with comorbidities). Respiratory samples (n = 74) were collected for viral culture, serum samples for measurement of IgM/IgG levels (n = 30), and plasma samples for levels of inflammatory cytokines and chemokines (n = 81). Disease severity was correlated with results from viral culture, sero..
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Awarded by Singapore National Medical Research Council COVID-19 Research Fund
Awarded by Singapore NMRC grants
Funding Acknowledgements
Recruitment of study participants and sample collection was supported by the Singapore National Medical Research Council COVID-19 Research Fund (grant number COVID19RF-001). The serology work was supported by Singapore NMRC grants STPRG-FY19-001 and COVID19RF-003. The multiplex microbead-based immunoassays were supported by core funds from the Singapore Immunology Network (A*STAR).