Viral dynamics and immune correlates of COVID-19 disease severity.
Barnaby E Young, Sean WX Ong, Lisa FP Ng, Danielle E Anderson, Wan Ni Chia, Po Ying Chia, Li Wei Ang, Tze-Minn Mak, Shirin Kalimuddin, Louis Yi Ann Chai, Surinder Pada, Seow Yen Tan, Louisa Sun, Purnima Parthasarathy, Siew-Wai Fong, Yi-Hao Chan, Chee Wah Tan, Bernett Lee, Olaf Rötzschke, Ying Ding Show all
Clinical Infectious Diseases | Published : 2020
BACKGROUND: Key knowledge gaps remain in the understanding of viral dynamics and immune response of SARS-CoV-2 infection. METHODS: We evaluated these characteristics and established their association with clinical severity in a prospective observational cohort study of 100 patients with PCR-confirmed SARS-CoV-2 infection (mean age 46 years, 56% male, 38% with comorbidities). Respiratory samples (n=74) were collected for viral culture, serum samples for measurement of IgM/IgG levels (n=30), and plasma samples for levels of inflammatory cytokines and chemokines (n=81). Disease severity was correlated with results from viral culture, serologic testing, and immune markers. RESULTS: 57 (57%) pati..View full abstract