Journal article
Antagonistic Pleiotropy and Fitness Trade-Offs Reveal Specialist and Generalist Traits in Strains of Canine Distemper Virus
Veljko M Nikolin, Klaus Osterrieder, Veronika von Messling, Heribert Hofer, Danielle Anderson, Edward Dubovi, Edgar Brunner, Marion L East
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2012
Abstract
Theoretically, homogeneous environments favor the evolution of specialists whereas heterogeneous environments favor generalists. Canine distemper is a multi-host carnivore disease caused by canine distemper virus (CDV). The described cell receptor of CDV is SLAM (CD150). Attachment of CDV hemagglutinin protein (CDV-H) to this receptor facilitates fusion and virus entry in cooperation with the fusion protein (CDV-F). We investigated whether CDV strains co-evolved in the large, homogeneous domestic dog population exhibited specialist traits, and strains adapted to the heterogeneous environment of smaller populations of different carnivores exhibited generalist traits. Comparison of amino acid ..
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Awarded by Deutsche Forschungsgemeinschaft (DFG) through (Genetic and Immunologic Determinants of Pathogen-Host Interactions) at the Centre of Infection Biology and Immunity (ZIBI) of the Humboldt University Berlin
Funding Acknowledgements
This study was funded by the Deutsche Forschungsgemeinschaft (DFG) through the GRAKO 1121 (Genetic and Immunologic Determinants of Pathogen-Host Interactions) at the Centre of Infection Biology and Immunity (ZIBI) of the Humboldt University Berlin, and the Leibniz Institute for Zoo and Wildlife Research Berlin. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.