Journal article

Connecting clusters of COVID-19: an epidemiological and serological investigation

Sarah Ee Fang Yong, Danielle Elizabeth Anderson, Wycliffe E Wei, Junxiong Pang, Wan Ni Chia, Chee Wah Tan, Yee Leong Teoh, Priyanka Rajendram, Matthias Paul Han Sim Toh, Cuiqin Poh, Valerie TJ Koh, Joshua Lum, Nur-Afidah Md Suhaimi, Po Ying Chia, Mark I-Cheng Chen, Shawn Vasoo, Benjamin Ong, Yee Sin Leo, Linfa Wang, Vernon JM Lee

The Lancet Infectious Diseases | ELSEVIER SCI LTD | Published : 2020

Abstract

BACKGROUND: Elucidation of the chain of disease transmission and identification of the source of coronavirus disease 2019 (COVID-19) infections are crucial for effective disease containment. We describe an epidemiological investigation that, with use of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological assays, established links between three clusters of COVID-19. METHODS: In Singapore, active case-finding and contact tracing were undertaken for all COVID-19 cases. Diagnosis for acute disease was confirmed with RT-PCR testing. When epidemiological information suggested that people might have been nodes of disease transmission but had recovered from illness, SARS-CoV-2 I..

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Grants

Awarded by National Research Foundation (Singapore)


Awarded by National Natural Science Foundation of China


Awarded by National Medical Research Council Singapore COVID19 research fund


Funding Acknowledgements

The development of serological tests was funded in part by a joint grant under the National Research Foundation (Singapore) and the National Natural Science Foundation of China (NRF2016NRFNSFC002-013). The study was partly funded by the National Medical Research Council Singapore) COVID19 research fund (COVID19RF-001). We thank our colleagues who contributed to the investigations, including the COVID-19 epidemiology workgroup, contact tracing team, and hospital epidemiology teams; and Viji Vijayan, Benson Ng, and Velraj Sivalingam, (Duke-National University of Singapore ABSL3 facility) for logistics management and assistance.