Journal article

Zika virus infection elicits auto-antibodies to C1q

Takaaki Koma, Veljko Veljkovic, Danielle E Anderson, Lin-Fa Wang, Shannan L Rossi, Chao Shan, Pei-Yong Shi, David W Beasley, Natalya Bukreyeva, Jeanon N Smith, Steven Hallam, Cheng Huang, Veronika von Messling, Slobodan Paessler

Scientific Reports | NATURE PUBLISHING GROUP | Published : 2018

Abstract

Zika virus (ZIKV) causes mostly asymptomatic infection or mild febrile illness. However, with an increasing number of patients, various clinical features such as microcephaly, Guillain-Barré syndrome and thrombocytopenia have also been reported. To determine which host factors are related to pathogenesis, the E protein of ZIKV was analyzed with the Informational Spectrum Method, which identifies common information encoded by primary structures of the virus and the respective host protein. The data showed that the ZIKV E protein and the complement component C1q cross-spectra are characterized by a single dominant peak at the frequency F = 0.338, suggesting similar biological properties. Indee..

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Grants

Awarded by Singapore Ministry of Health's National Medical Research Council under Zika Response Research Fund


Awarded by CDC grant


Awarded by UTMB CTSA


Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES


Funding Acknowledgements

T.K. was supported by in part by a JSPS Postdoctoral Fellowship for Research Abroad. D.E.A and L.-F.W.'s research is supported by the Singapore Ministry of Health's National Medical Research Council under its Zika Response Research Fund (NMRC/ZRRF/0002/2016). P.-Y.S. lab was supported by University of Texas Medical Branch (UTMB) startup award, University of Texas STARs Award, CDC grant for the Western Gulf Center of Excellence for Vector-Borne Diseases, Pan American Health Organization grant SCON2016-01353, and UTMB CTSA UL1TR-001439. Sera from WNV-infected mice were generated on studies funded by the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation.