Journal article
Serological evidence of human infection by bat orthoreovirus in Singapore
Anna Uehara, Chee Wah Tan, Shailendra Mani, Kaw Bing Chua, Yee Sin Leo, Danielle E Anderson, Lin-Fa Wang
Journal of Medical Virology | WILEY | Published : 2019
DOI: 10.1002/jmv.25355
Abstract
To determine whether Pteropine orthoreovirus (PRV) exposure has occurred in Singapore, we tested 856 individuals from an existing serum panel collected from 2005-2013. After an initial screen with luciferase immunoprecipitation system and secondary confirmation with virus neutralization test, we identified at least seven individuals with specific antibodies against PRV in both assays. Our findings confirm that PRV spillover into human populations is relatively common in this region of the world.
Grants
Awarded by Ministry of Defence, Singapore
Awarded by National reserach foundation, Singapore
Awarded by Ministry of Health, Singapore
Awarded by National Medical Research Council, Singapore
Funding Acknowledgements
Ministry of Defence, Singapore, Grant/Award Number: DIRP2015-9016102060; National reserach foundation, Singapore, Grant/Award Number: NRF2012NRF-CRP001-056; Ministry of Health, Singapore, Grant/Award Number: CDPHRG/0006/2014; National Medical Research Council, Singapore, Grant/Award Number: ZRRF16006; CD-PHRG; NRF-CRP; NMRC; MINDEF