Journal article

Serological evidence of human infection by bat orthoreovirus in Singapore

Anna Uehara, Chee Wah Tan, Shailendra Mani, Kaw Bing Chua, Yee Sin Leo, Danielle E Anderson, Lin-Fa Wang

Journal of Medical Virology | WILEY | Published : 2019


To determine whether Pteropine orthoreovirus (PRV) exposure has occurred in Singapore, we tested 856 individuals from an existing serum panel collected from 2005-2013. After an initial screen with luciferase immunoprecipitation system and secondary confirmation with virus neutralization test, we identified at least seven individuals with specific antibodies against PRV in both assays. Our findings confirm that PRV spillover into human populations is relatively common in this region of the world.


Awarded by Ministry of Defence, Singapore

Awarded by National reserach foundation, Singapore

Awarded by Ministry of Health, Singapore

Awarded by National Medical Research Council, Singapore

Funding Acknowledgements

Ministry of Defence, Singapore, Grant/Award Number: DIRP2015-9016102060; National reserach foundation, Singapore, Grant/Award Number: NRF2012NRF-CRP001-056; Ministry of Health, Singapore, Grant/Award Number: CDPHRG/0006/2014; National Medical Research Council, Singapore, Grant/Award Number: ZRRF16006; CD-PHRG; NRF-CRP; NMRC; MINDEF