Journal article

Beilong virus, a novel paramyxovirus with the largest genome of non-segmented negative-stranded RNA viruses

Z Li, M Yu, H Zhang, DE Magoffin, PJM Jack, A Hyatt, HY Wang, LF Wang

Virology | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2006

Abstract

During a subtraction study on gene expression in human kidney mesangial cells (HMCs), cDNA clones with sequence homology to paramyxovirus P, M and F genes were isolated. Subsequent investigation revealed that this particular HMC line was infected with a previously unknown paramyxovirus. Here, we report the isolation and genome characterization of this new virus, now named Beilong virus (BeV). The genome of BeV is 19,212 nucleotides (nt) in length and is the largest among all known members of the order Mononegavirales. The BeV genome contains eight genes in the order 3'-N-P/V/C-M-F-SH-TM-G-L-5'. The SH and TM genes code for a small hydrophobic protein of 76 aa and a transmembrane protein of 2..

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