OS06.5 YAP is essential for glioblastoma proliferation and survival in vitro and in vivo

Abstract

Introduction: Despite improved understanding of the genomic basis of glioma, the prognosis for patients with glioblastoma multiforme (GBM) remains dismal. Targeting glioma stem cell signalling pathways may provide novel therapeutic opportunities. Yes-associated protein (YAP) is downstream of the Hippo pathway and is a key regulator of organogenesis and an emerging oncogene. It is a transcriptional co-factor active in stem cell niches that promotes proliferation and migration and inhibits apoptosis and differentiation. There is mounting evidence that YAP is important in many solid malignancies, however its role in GBM is poorly understood. Methods: Mutation, copy number, gene expression and c..