Journal article

Tumor sink effect in 68Ga-PSMA-11 PET: Myth or Reality?

Andrei Gafita, Hui Wang, Andrew Robertson, Wesley Robert Armstrong, Raphael Zaum, Manuel Weber, Farid Yagubbayli, Clemens Kratochwil, Tristan R Grogan, Kathleen Nguyen, Fernando Navarro, Rouzbeh Esfandiari, Isabel Rauscher, Bjoern Menze, David Elashoff, Ebrahim S Delpassand, Ken Herrmann, Johannes Czernin, Michael S Hofman, Jeremie Calais Show all

J Nucl Med | Published : 2021

Abstract

Background: We aimed to systematically determine the impact of tumor burden on the 68Ga-prostate-specific membrane antigen-11 (68Ga-PSMA) PET biodistribution by the use of quantitative measurements. Methods: This international multicenter retrospective analysis included 406 men with prostate cancer who received 68Ga-PSMA PET/CT. Of these, 356 had positive findings and were stratified by quintiles into very low (Q1, ≤25 ml), low (Q2, 25-189 ml), moderate (Q3, 189-532 ml), high (Q4, 532-1355 ml) and very high (Q5, ≥1355 ml) total PSMA-positive tumor volume (PSMA-VOL). PSMA-VOL was obtained by semi-automatic segmentation of total tumor lesions using qPSMA software. Fifty prostate cancer patient..

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