Journal article
White Matter Disruption in Pediatric Traumatic Brain Injury: Results From ENIGMA Pediatric Moderate to Severe Traumatic Brain Injury
EL Dennis, K Caeyenberghs, KR Hoskinson, TL Merkley, SJ Suskauer, RF Asarnow, T Babikian, B Bartnik-Olson, K Bickart, ED Bigler, L Ewing-Cobbs, A Figaji, CC Giza, NJ Goodrich-Hunsaker, CB Hodges, ES Hovenden, A Irimia, M Königs, HS Levin, HM Lindsey Show all
Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021
Abstract
ObjectiveOur study addressed aims (1) to test the hypothesis that moderate-severe traumatic brain injury (TBI) in pediatric patients is associated with widespread white matter (WM) disruption, (2) to test the hypothesis that age and sex affect WM organization after injury, and (3) to examine associations between WM organization and neurobehavioral outcomes.MethodsData from 10 previously enrolled, existing cohorts recruited from local hospitals and clinics were shared with the Enhancing NeuroImaging Genetics Through Meta-Analysis (ENIGMA) Pediatric Moderate/Severe TBI (msTBI) working group. We conducted a coordinated analysis of diffusion MRI (dMRI) data using the ENIGMA dMRI processing pipel..
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Awarded by U.S. Department of Defense
Funding Acknowledgements
Funding provided by K99NS096116 (E.L.D.); R61NS120249 (E.L.D., D.F.T., E.A.W.); R01NS05400 (B.B.-O.); National Health and Medical Research Council Career Development Fellowship (K.C.); NRF SARChI Chair of Clinical Neurosciences (A.F.); UCLA Easton Clinic for Brain Health, Stan and Patty Silver, UCLA Brain Injury Research Center, R01HD061504 (C.C.G.); K01HD083459 (K.R.H.); R01NS100973, Department of Defense contract W81XWH-18-1-0413 and a Hanson-Thorell Research Scholarship (A.I.); R01HD088438 (JEM); K12HD001097, K23HD06161, UL1TR001079, 1S10OD021648 (S.J.S.); U54EB020403, R01MH116147, R56AG058854, P41EB015922, R01MH111671 (P.M.T.); K99MH119314, NARSAD 27786 (B.S.C.W.); and Ronald and Irene Ward Chair in Pediatric Brain Injury, funded by the Alberta Children's Hospital Foundation (K.O.Y.).