Journal article
Sedative-hypnotic effect and in silico study of dinaphthodiospyrols isolated from Diospyros lotus Linn
YS Al-Awthan, A Rauf, U Rashid, S Bawazeer, S Naz, O Bahattab, S Bawazeer, N Muhammad, DS Waggas, GES Batiha, MA Shariati, M Derkho, HAR Suleria
Biomedicine and Pharmacotherapy | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | Published : 2021
Abstract
Traditionally, Diospyros lotus Linn is used for insomnia and other associated disorders. Insomnia is a worldwide disorder with different etiology which is treated with different synthetic medicine associated with addiction. Natural products are generally devoid of such addition with good efficacy. Current research was conducted to evaluate the sedative and hypnotic effects of dimeric naphthoquinones such as dinaphthodiospyrol A (1), dinaphthodiospyrol B (2), dinaphthodiospyrol C (3), dinaphthodiospyrol D (4), dinaphthodiospyrol E (5) and dinaphthodiospyrol F (6) isolated from the chloroform fractions of D. lotus. The sedative and hypnotic effects at the dose of 5 and 10 mg/kg (each compound)..
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Funding Acknowledgements
The work is funded by grant number 14-MED333-10 from the National Science, Technology and Innovation Plan (MAARIFAH), the King Abdul-Aziz City for Science and Technology (KACST), Kingdom of Saudi Arabia. We thank the Science and Technology Unit at Umm Al-Qura University for their continued logistic support.