Tissue-resident regulatory T cells accumulate at human barrier lymphoid organs
Rehana Hewavisenti, Angela L Ferguson, Georgia Gasparini, Tomoki Ohashi, Asolina Braun, Thomas S Watkins, John J Miles, Michael Elliott, Frederic Sierro, Carl G Feng, Warwick J Britton, Thomas Gebhardt, Stuart Tangye, Umaimainthan Palendira
IMMUNOLOGY AND CELL BIOLOGY | WILEY | Published : 2021
Regulatory T cells (Tregs) play a critical role in immune regulation and peripheral tolerance. While different types of Tregs have been identified in both mice and humans, much of our understanding about how these cells maintain immune homeostasis is derived from animal models. In this study, we examined two distinct human lymphoid organs to understand how repeated exposure to infections at the mucosal surface influences the phenotype and tissue localization of Tregs. We show that while Tregs in both tonsils and spleen express a tissue-resident phenotype, they accumulate in greater numbers in tonsils. Tonsillar-resident Tregs exhibit a highly suppressive phenotype with significantly increase..View full abstract
This project was supported by grants from the National Health and Medical Research Council (NHMRC) of Australia and the NSW Government Infrastructure Grant to the Centenary Institute. We thank the Australian Centre for Microscopy & Microanalysis and Sydney Cytometry at the University of Sydney for their assistance with this work.