Prospective Phase II trial of radiation therapy in localised non-gastric marginal zone lymphoma with prospective evaluation of autoimmunity and Helicobacter pylori status: TROG 05.02/ALLG NHL15
Michael P MacManus, Daniel Roos, Peter O'Brien, Anne Capp, Andrew Wirth, Richard Tsang, Mathias Bressel, Stephen Lade, John F Seymour
EUROPEAN JOURNAL OF CANCER | ELSEVIER SCI LTD | Published : 2021
BACKGROUND: This Phase 2 multicentre trial in localised non-gastric marginal zone lymphoma (MZL) evaluated the effectiveness and safety of radiotherapy and documented markers of autoimmunity and Helicobacter pylori infection. PATIENTS AND METHODS: Eligible patients had Stages I and II or paired-organ, non-gastric MZL. Bone marrow evaluation, autoantibody panel, and H. pylori evaluation were mandatory. Involved-field or involved-site radiotherapy was delivered to 24-30.6 Gy. Detected H. pylori infections underwent eradication. RESULTS: Between 2006 and 2014, six centres enrolled 70 patients, and 68 commenced treatment. The median age was 59 (range: 23-84) years, and 31 (46%) were male. Overal..View full abstract
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Awarded by Australian National Health and Medical Research Council
This trial was supported by a grant from the Australian National Health and Medical Research Council [Grant Number 454382].