Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

GAM Blokland; J Grove; CY Chen; C Cotsapas; S Tobet; R Handa; D St Clair; T Lencz; BJ Mowry; S Periyasamy; MJ Cairns; PA Tooney; JQ Wu; B Kelly; G Kirov; PF Sullivan; A Corvin; BP Riley; T Esko; L Milani; EG Jönsson; A Palotie; H Ehrenreich; M Begemann; A Steixner-Kumar; PC Sham; N Iwata; DR Weinberger; PV Gejman; AR Sanders; JD Buxbaum; D Rujescu; I Giegling; B Konte; AM Hartmann; E Bramon; RM Murray; MT Pato; J Lee; I Melle; E Molden; RA Ophoff; A McQuillin; NJ Bass; R Adolfsson; AK Malhotra; NG Martin; JM Fullerton; PB Mitchell; PR Schofield; AJ Forstner; F Degenhardt; S Schaupp; AL Comes; M Kogevinas; J Guzman-Parra; A Reif; F Streit; L Sirignano; S Cichon; M Grigoroiu-Serbanescu; J Hauser; J Lissowska; F Mayoral; B Müller-Myhsok; B Swiatkowska; TG Schulze; MM Nöthen; M Rietschel; J Kelsoe; M Leboyer; S Jamain; B Etain; F Bellivier; JB Vincent; M Alda; C O'Donovan; P Cervantes; JM Biernacka; M Frye; SL McElroy; LJ Scott; EA Stahl; M Landén; ML Hamshere; OB Smeland; S Djurovic; AE Vaaler; OA Andreassen; BT Baune; TM Air; M Preisig; R Uher; DF Levinson; MM Weissman; JB Potash; J Shi; JA Knowles; RH Perlis; S Lucae

Journal article

Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

GAM Blokland, J Grove, CY Chen, C Cotsapas, S Tobet, R Handa, D St Clair, T Lencz, BJ Mowry, S Periyasamy, MJ Cairns, PA Tooney, JQ Wu, B Kelly, G Kirov, PF Sullivan, A Corvin, BP Riley, T Esko, L Milani Show all

Biological Psychiatry | Published : 2022

DOI: 10.1016/j.biopsych.2021.02.972

Abstract

Background: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. Methods: We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,946 controls from the PGC (Psychiatric Genomics Consortium) and iPSYCH. Results: Across disorders, genome-wide significant single nucleotide polymorphism–by-sex interaction was detected for a locus enco..

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