Journal article

Molecular mechanisms of cell death in neurological diseases

Diane Moujalled, Andreas Strasser, Jeffrey R Liddell



Tightly orchestrated programmed cell death (PCD) signalling events occur during normal neuronal development in a spatially and temporally restricted manner to establish the neural architecture and shaping the CNS. Abnormalities in PCD signalling cascades, such as apoptosis, necroptosis, pyroptosis, ferroptosis, and cell death associated with autophagy as well as in unprogrammed necrosis can be observed in the pathogenesis of various neurological diseases. These cell deaths can be activated in response to various forms of cellular stress (exerted by intracellular or extracellular stimuli) and inflammatory processes. Aberrant activation of PCD pathways is a common feature in neurodegenerative ..

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Awarded by National Health and Medical Research Council (NHMRC)

Awarded by Leukaemia and Lymphoma Society (LLS) SCOR Grant

Funding Acknowledgements

Work by the authors is supported in part by a National Health and Medical Research Council (NHMRC) Programme Grant #101671 awarded to AS, NHMRC Fellowship #1020363 awarded to AS, Leukaemia and Lymphoma Society (LLS) SCOR Grant #7001-13, awarded to AS; the estate of Anthony (Toni) Redstone OAM awarded to AS and operational infrastructure grants through the Australian Government NHMRCS IRIISS and the Victorian State Government Operational Infrastructure Support.