Journal article
HIV is associated with an increased risk of age-related clonal hematopoiesis among older adults
NJ Dharan, P Yeh, M Bloch, MM Yeung, D Baker, J Guinto, N Roth, S Ftouni, K Ognenovska, D Smith, JF Hoy, I Woolley, C Pell, DJ Templeton, N Fraser, N Rose, J Hutchinson, K Petoumenos, SJ Dawson, MN Polizzotto Show all
Nature Medicine | Published : 2021
Abstract
People with human immunodeficiency virus (HIV) have higher rates of certain comorbidities, particularly cardiovascular disease and cancer, than people without HIV1–5. In view of observations that somatic mutations associated with age-related clonal hematopoiesis (CH) are linked to similar comorbidities in the general population6–10, we hypothesized that CH may be more prevalent in people with HIV. To address this issue, we established a prospective cohort study, the ARCHIVE study (NCT04641013), in which 220 HIV-positive and 226 HIV-negative participants aged 55 years or older were recruited in Australia. Demographic characteristics, clinical data and peripheral blood were collected to assess..
View full abstractGrants
Awarded by Howard Hughes Medical Institute
Funding Acknowledgements
The authors thank all of the individuals who participated in this study. We also acknowledge the following clinical site study coordinators: T. Vincent, Holdsworth House Medical Practice; R. Rosario, East Sydney Doctors; H. Lau, Prahran Market Clinic; F. Bascombe, St Vincent's Hospital Sydney; D. Smith, Albion Centre; S. Price, Alfred Hospital; J. O'Brien, Monash Health; H. T. L. Tan, Taylor Square Private Clinic; B. Sinclair, Department of Sexual Health Medicine, Sydney Local Health District. We also acknowledge K. Merlin, M. Starr, B. Catlett and the Clinical Trials & Biorepository/DBS Team at St Vincent's Centre for Applied Medical Research. Finally, we acknowledge P. Blombery, M. McBean and H. N. Goh for their assistance with ASXL1 fragment-length analysis. The Kirby Institute receives funding from the Australian Government Department of Health and Ageing. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Australian Government. We thank the following funders for fellowship and grant support: NHMRC investigator grant (1196749 to. M.A.D.), Cancer Council Victoria Dunlop Fellowship (to M.A. D.), Howard Hughes Medical Institute international research scholarship (to M. A.D.), NHMRC investigator grant (1196755 to S.-J.D.), CSL Centenary fellowship (to S.-J.D.), NHMRC postgraduate scholarship (to N.J.D.), NHMRC fellowship (1110067 to M.N.P.), Cancer Institute of NSW Future Research Leader Fellowship (15-1-01 to M.N.P.), NHMRC/MRFF investigator grant (1195030 to P.Y.), Snowdome Foundation/Maddie Riewoldt's vision (to P.Y.), George and Yolanda Klempfner AO fellowship (to P.Y.), Gilead (to P.Y.) and NHMRC project grants (1128984 (to S.-J.D. and M.A.D.) and 1213110).