Infection-Related Mortality in Adults and Children Undergoing Allogeneic Hematopoietic Cell Transplantation: An Australian Registry Report
Julian Lindsay, Ian Kerridge, Leonie Wilcox, Steven Tran, Tracey A O'Brien, Matthew Greenwood, Sharon C-A Chen, David CM Kong, Steven A Pergam, Catherine Liu, Monica A Slavin
TRANSPLANTATION AND CELLULAR THERAPY | ELSEVIER SCIENCE INC | Published : 2021
Infection-related mortality (IRM) is the most common non-relapse-related cause of death reported after allogeneic hematopoietic cell transplantation (HCT). Information on the incidence and timing of specific infective organisms and the risk factors for IRM is essential to developing prevention strategies. This report provides the first account of IRM in adults and children undergoing HCT in Australia. Between 2013 and 2018, 2705 adult and 689 pediatric first HCTs were identified from the Australasian Bone Marrow Transplant Recipient Registry database, associated with 1075 (39.7%) total overall deaths in adults and 134 (19.4%) in children. Demographics and causes of death, including infectiou..View full abstract
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Awarded by National Health and Medical Research Council Centres of Research Excellence and Investigator Grants
J.L. is supported by a Leukaemia Foundation and Haematology Society of Australia and a New Zealand NewInvestigator PhD Scholarship. M.S. is supported by National Health and Medical Research Council Centres of Research Excellence and Investigator Grants (1116876 and 1173791).