Journal article

Exercise mimetics: harnessing the therapeutic effects of physical activity

Carolina Gubert, Anthony J Hannan

NATURE REVIEWS DRUG DISCOVERY | NATURE RESEARCH | Published : 2021

Abstract

Exercise mimetics are a proposed class of therapeutics that specifically mimic or enhance the therapeutic effects of exercise. Increased physical activity has demonstrated positive effects in preventing and ameliorating a wide range of diseases, including brain disorders such as Alzheimer disease and dementia, cancer, diabetes and cardiovascular disease. This article discusses the molecular mechanisms and signalling pathways associated with the beneficial effects of physical activity, focusing on effects on brain function and cognitive enhancement. Emerging therapeutic targets and strategies for the development of exercise mimetics, particularly in the field of central nervous system disorde..

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Grants

Funding Acknowledgements

The authors thank past and present members of the Hannan Laboratory for experimental data and discussions that have informed the ideas presented in this article. A.J.H. is a National Health and Medical Research Council (NHMRC) Principal Research Fellow and is supported by Projects Grants and an Ideas Grant from the NHMRC and a Discovery Project Grant from the Australian Research Council, as well as the DHB Foundation, Equity Trustees.