Blood Pressure Variability and Nocturnal Dipping in Diabetic Patients With and Without Chronic Kidney Disease

Abstract

Background: Both increased blood pressure variability (BPV) and lack of nocturnal blood pressure dipping (NBPD) are independently associated with excess mortality in patients with diabetes mellitus. We hypothesised that patients with diabetes and CKD have higher BPV and are more likely to demonstrate a lack of nocturnal blood pressure dipping, than their counterparts without CKD. Methods: Clinical and biochemical data were collected from 124 patients attending diabetes clinics at Austin Health, Melbourne Australia. Stage 3 to 5 CKD (from here on referred to as “CKD”) was defined by a CKD-EPI eGFR of <60ml/min/1.73m2. Patients underwent 24h ambulatory blood pressure monitori..