O45-3 Occupational risk factors for motor neurone disease: a new zealand population-based case-control study

Abstract

Apart from increasing age and a few specific genetic polymorphisms, the aetiology of Motor Neurone Disease is largely unknown. Only 5–10% of cases are familial with the vast majority being of the sporadic form. A role for environmental exposures is suggested by the lack of evidence for a genetic component, differences in incidence by geographical region, increases in incidence observed in some countries (including New Zealand) over a relatively short period, associations observed in epidemiological studies, and the higher proportion of males affected. We conducted a New Zealand population-based case-control study to investigate associations between occupational exposures and MND. We recruite..