The acidic nature of the CcmG redox-active center is important for cytochrome c maturation in Escherichia coli.
Melissa A Edeling, Umesh Ahuja, Begoña Heras, Linda Thöny-Meyer, Jennifer L Martin
J Bacteriol | American Society for Microbiology | Published : 2004
Cytochrome c biogenesis in Escherichia coli is a complex process requiring at least eight genes (ccmABCDEFGH). One of these genes, ccmG, encodes a thioredoxin-like protein with unusually specific redox activity. Here, we investigate the basis for CcmG function and demonstrate the importance of acidic residues surrounding the redox-active center.